Therapeutic effects of Trilovin
250 in the Treatment of Functional Erectile Disorders
Roumen Bostandjiev, M.D., Ph.D.
Assistant Professor, Department of Sexology,
Medical University-Sofia, Bulgaria
Introduction
According to recent research, more then 50% of men of reproductive age suffer from erectile disorders. Interest in pharmacological
treatment of erectile dysfunction has risen enormously as a result of the sensational advertisement of new medications like Viagra and Coverject.
Economic constraints make these medications unavailable to most Bulgarians, whose attitudes are characterized by pragmatic materialism and
expectations of receiving low cost medications.
Our experience in the Department of Sexology in the Medical University-Sofia, of Bulgaria, is unique and has convinced us that positive results in the
treatment of functional erectile disorders are attainable when we combine traditional sex therapy modeled after W. Masters & V. Johnson (1972, 1979,
and 1980) and H.S. Kaplan (1974) with small doses of anxiolytics (Xanax 0.5 mg.) and a stimulant for sexual activity.
Our interest in Trilovin 250 derives from the following facts:
- Previous research has shown that Trilovin 250 has complex effects on human sexuality that can be sustained over time.
- Trilovin 250 is easy to take and does not create the anxiety related to performance expectations that are associated with aphrodisiacs, which must
be taken immediately before sexual intercourse.
- Trilovin 250 is not so expensive as to make it unattainable for Bulgarians.
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Research Goal
To
investigate the therapeutic effect of Trilovin 250 in the treatment of functional erectile disorders by comparing its effects in monotherapy and in
combination with traditional psychotherapy.
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Study Design
- We formed two clinical groups of patients with functional erectile disorders as follows:
- Group A: Patients were treated only with Trilovin 250 in doses of 2 tablets each in the morning and 2 tablets each in the evening.
- Group B: Patients were treated with Trilovin 250 as outlined in Group A, in combination with psychotherapy.
- Each of the patients involved in this study passed through the following clinical sessions:
- First Session for diagnostic clarification (included was the administration of a special psychometric inventory for self-reporting of sexual
functioning, in addition to clinical investigations to establish that there was no somatic reason for erectile dysfunction).
- Second Session for evaluation of therapeutic results and additional treatment for stabilizing improvements.
- Third Session for final evaluation and discussion of treatment.
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Research Instrument
For the purposes of this research, we created a special paper-and-pencil, psychometric inventory for self-evaluation of sexual functioning:
- The purpose of the following questions was to make a distinction between functional and other types of erectile dysfunction.
- Did you have sufficient night or morning erections last month?
- Did you have a good erection at the time of masturbation or other sexual stimulation, excluding intercourse?
- Did you have a good erection when you were with your partner and there was no opportunity for intercourse?
- The following questions were used for evaluation of therapeutic results.
The purpose was to clarify the extent of erectile dysfunction and level of sexual interest (libido).
a) How often last month have you experienced difficulties during sexual intercourse due to insufficient erection?
Very often
Often
Rare
I had no difficulties
b) Compare your sexual desire (libido) last month with your usual sexual desire.
My desire was strongly diminished
My desire was somewhat diminished
There was no change in my desire
My desire was greater
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Research Results
- Data concerning change in the quality of erection.
Group A: Patients treated only with Trilovin 250
(Table 1)
| Extent of erectile dysfunction |
How often last month have you experienced difficulties during intercourse due to insufficient erection?
|
|
Very often |
Often |
Rare |
I had no difficulties with erection |
Number of patients |
| First Session (beginning of therapy) |
5 |
5 |
2 |
0 |
12 |
| Second Session (one month later) |
0 |
1 |
5 |
6 |
12 |
| Third Session (two months later) |
0 |
1 |
4 |
7 |
12 |
Group B: Patients treated with Trilovin 250 and psychotherapy
(Table 2)
| Extent of erectile dysfunction |
How often last month have you experienced difficulties during intercourse due to insufficient erection?
|
|
Very often |
Often |
Rare |
I had no difficulties with erection |
Number of patients |
| First Session (beginning of therapy) |
5 |
5 |
2 |
0 |
12 |
| Second Session (one month later) |
1 |
2 |
5 |
4 |
12 |
| Third Session (two months later) |
2 |
1 |
4 |
5 |
12 |
- Data concerning changes in sexual desire (libido).
Group A: Patients treated only with Trilovin 250
(Table 3)
| Change in libido |
Compare your sexual desire (libido) last month with your usual sexual desire? |
|
Strongly Dimi-
nished |
Somewhat Dimi-
nished |
No change |
Greater |
Number of patients |
| First Session (beginning of therapy) |
3 |
6 |
3 |
0 |
12 |
| Second Session (one month later) |
0 |
5 |
3 |
4 |
12 |
| Third Session (two months later) |
0 |
2 |
6 |
4 |
12 |
Group B: Patients treated with Trilovin 250 and psychotherapy
(Table 4)
| Change in libido |
Compare your sexual desire (libido) last month with your usual sexual desire? |
|
Strongly Dimi-
nished |
Somewhat Dimi-
nished |
No change |
Greater |
Number of patients |
| First Session (beginning of therapy) |
4 |
6 |
2 |
0 |
12 |
| Second Session (one month later) |
0 |
4 |
3 |
5 |
12 |
| Third Session (two months later) |
0 |
1 |
5 |
6 |
12 |
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Conclusions
We were able to make the following preliminary conclusions without sophisticated statistical analysis of the data as a result of the size and scope of
this study and the preponderance of the results. It is our belief that more extensive investigations will validate these conclusions.
- Trilovin 250 has excellent therapeutic effects on functionally impaired erections.
- After two months of treatment with Trilovin 250, results in both clinical groups were better than the results after one month of treatment. This
suggests that prolonged treatment with this medication increases the chances of improvement in functional erectile disorders.
- When Trilovin 250 is combined with psychotherapy, results in the treatment of erectile dysfunction are better.
- Trilovin 250 improves not only the quality of erection but also raises the level of sexual desire (libido). This effect was more marked after two
months of treatment with this medication than after one month.
- Greater sexual desire is more pronounced when Trilovin 250 is combined with psychotherapy. We believe these two elements in the therapy of
functional erectile disorders are mutually beneficial.
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Recommendations
Results of this clinical research give us reason to strongly recommend the inclusion of Trilovin 250 in a routine therapeutic program for
patients with functional erectile dysfunction. This recommendation may be included in the following materials:
- Courses on sexuality counseling for postgraduate faculty of the Medical University-Sofia.
- 2000 editions of Sexuality and Health, Sexology for General Practitioners, and Sexology and Family Planning.
- Articles for scientific journals and presentations at conferences concerning sexual dysfunction.
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